Heparin and cancer revisited: mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis.

@article{Borsig2001HeparinAC,
  title={Heparin and cancer revisited: mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis.},
  author={Lubor Borsig and Richard Kwok-Shing Wong and James R. Feramisco and Daniel R. Nadeau and Nissi M. Varki and Ajit Varki},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 6},
  pages={3352-7}
}
Independent studies indicate that expression of sialylated fucosylated mucins by human carcinomas portends a poor prognosis because of enhanced metastatic spread of tumor cells, that carcinoma metastasis in mice is facilitated by formation of tumor cell complexes with blood platelets, and that metastasis can be attenuated by a background of P-selectin deficiency or by treatment with heparin. The effects of heparin are not primarily due to its anticoagulant action. Other explanations have been… CONTINUE READING
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Developments in Oncology 7: Tumor Invasion and Metastasis (Martinus Nijhoff, The Hague)

  • I. R. Hart, L. A. Liotta
  • 1982

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