Heparin Decreases in Tumor Necrosis Factor α (TNFα)-induced Endothelial Stress Responses Require Transmembrane Protein 184A and Induction of Dual Specificity Phosphatase 1.

@article{Farwell2016HeparinDI,
  title={Heparin Decreases in Tumor Necrosis Factor α (TNFα)-induced Endothelial Stress Responses Require Transmembrane Protein 184A and Induction of Dual Specificity Phosphatase 1.},
  author={Sara Lynn N. Farwell and Daniela Kanyi and Marianne Hamel and Joshua B Slee and Elizabeth A Miller and Mark David Cipolle and Linda J. Lowe-Krentz},
  journal={The Journal of biological chemistry},
  year={2016},
  volume={291 10},
  pages={
          5342-54
        }
}
Despite the large number of heparin and heparan sulfate binding proteins, the molecular mechanism(s) by which heparin alters vascular cell physiology is not well understood. Studies with vascular smooth muscle cells (VSMCs) indicate a role for induction of dual specificity phosphatase 1 (DUSP1) that decreases ERK activity and results in decreased cell proliferation, which depends on specific heparin binding. The hypothesis that unfractionated heparin functions to decrease inflammatory signal… CONTINUE READING
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