Heparanase tailors syndecan for exosome production.

@article{David2016HeparanaseTS,
  title={Heparanase tailors syndecan for exosome production.},
  author={Guido David and Pascale Zimmermann},
  journal={Molecular & cellular oncology},
  year={2016},
  volume={3 3},
  pages={e1047556}
}
Exosomes are secreted vesicles involved in signaling processes. The biogenesis of a class of these vesicles depends on syntenin and syndecans. Heparanase acts as a regulator of the syndecan-syntenin-exosome biogenesis pathway. The upregulation of syntenin and heparanase in cancers may support the suspected roles of exosomes in tumor biology. 

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