Heparanase procoagulant activity as a predictor of wound necrosis following diabetic foot amputation.

@article{Peled2016HeparanasePA,
  title={Heparanase procoagulant activity as a predictor of wound necrosis following diabetic foot amputation.},
  author={Eli Peled and Eyal A Melamed and Tali Banker Portal and Elena Axelman and Doron Norman and Benjamin R Brenner and Yona Nadir},
  journal={Thrombosis research},
  year={2016},
  volume={139},
  pages={148-53}
}
BACKGROUND Trans-metatarsal operation to diabetic foot necrosis is a common procedure although only half of the patients do not need a second amputation due to surgery wound ischemia. No current tools are available for early prediction of surgery success and the clinical decision for a second operation may take weeks. Heparanase protein is involved in inflammation, angiogenesis and coagulation activation. The aim of the study was to evaluate heparanase level and procoagulant activity as an… CONTINUE READING
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