Heparanase induces Akt phosphorylation via a lipid raft receptor.


The endoglycosidase heparanase is the predominant enzyme that degrades heparan sulfate side chains of heparan sulfate proteoglycans, activity that is strongly implicated in tumor metastasis. Apart of its well characterized enzymatic activity, heparanase was noted to exert also enzymatic-independent functions. Among these is the induction of Akt/PKB… (More)



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@article{BenZaken2007HeparanaseIA, title={Heparanase induces Akt phosphorylation via a lipid raft receptor.}, author={Olga Ben-Zaken and Svetlana Gingis-Velitski and Israel Vlodavsky and Neta Ilan}, journal={Biochemical and biophysical research communications}, year={2007}, volume={361 4}, pages={829-34} }