Heparanase induced by advanced glycation end products (AGEs) promotes macrophage migration involving RAGE and PI3K/AKT pathway

@inproceedings{Qin2013HeparanaseIB,
  title={Heparanase induced by advanced glycation end products (AGEs) promotes macrophage migration involving RAGE and PI3K/AKT pathway},
  author={Qiaojing Qin and Jianying Niu and Zhaoxia Wang and Wangjie Xu and Zhongdong Qiao and Yong Gu},
  booktitle={Cardiovascular diabetology},
  year={2013}
}
BACKGROUND Advanced glycation end products (AGEs), inflammatory-associated macrophage migration and accumulation are crucial for initiation and progression of diabetic vascular complication. Enzymatic activity of heparanase (HPA) is implicated strongly in dissemination of metastatic tumor cells and cells of the immune system. In addition, HPA enhances the phosphorylation of selected signaling molecules including AKT pathway independent of enzymatic activity. However, virtually nothing is… CONTINUE READING