Heparanase and macrophage interplay in the onset of liver fibrosis

Abstract

The heparan sulfate endoglycosidase heparanase (HPSE) is involved in tumor growth, chronic inflammation and fibrosis. Since a role for HPSE in chronic liver disease has not been demonstrated to date, the current study was aimed at investigating the involvement of HPSE in the pathogenesis of chronic liver injury. Herein, we revealed that HPSE expression… (More)
DOI: 10.1038/s41598-017-14946-0

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