Heparanase: busy at the cell surface.

  title={Heparanase: busy at the cell surface.},
  author={Liat Fux and Neta Ilan and Ralph D. Sanderson and Israel Vlodavsky},
  journal={Trends in biochemical sciences},
  volume={34 10},
Heparanase activity is strongly implicated in structural remodeling of the extracellular matrix, a process which can lead to invasion by tumor cells. In addition, heparanase augments signaling cascades leading to enhanced phosphorylation of selected protein kinases and increased gene transcription associated with aggressive tumor progression. This function is apparently independent of heparan sulfate and enzyme activity, and is mediated by a novel protein domain localized at the heparanase C… CONTINUE READING

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