Heparanase, tissue factor, and cancer.

@article{Nadir2008HeparanaseTF,
  title={Heparanase, tissue factor, and cancer.},
  author={Yona Nadir and Israel Vlodavsky and Benjamin Brenner},
  journal={Seminars in thrombosis and hemostasis},
  year={2008},
  volume={34 2},
  pages={
          187-94
        }
}
Heparanase is an endo-beta- D-glucuronidase that is capable of cleaving heparan sulfate side chains of heparan sulfate proteoglycans on cell surfaces and the extracellular matrix, activity that is strongly implicated in tumor metastasis and angiogenesis. Evidence was provided that heparanase overexpression in human leukemia, glioma, and breast carcinoma cells results in a marked increase in tissue factor (TF) levels. Likewise, TF was induced by exogenous addition of recombinant heparanase to… CONTINUE READING

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