Heparanase, hyaluronan, and CD44 in cancers: a breast carcinoma perspective.

  title={Heparanase, hyaluronan, and CD44 in cancers: a breast carcinoma perspective.},
  author={Martin G{\"o}tte and George W-C Yip},
  journal={Cancer research},
  volume={66 21},
Glycosaminoglycans are major constituents of the cancer cell surface and the tumor stroma. The heparan sulfate degrading enzyme heparanase, hyaluronan, and its receptor CD44 are up-regulated in breast cancer, generating a microenvironment that promotes tumor progression and metastasis. Recent experimental and clinical evidence shows that heparanase, hyaluronan, and CD44 regulate cancer cell proliferation, migration, and invasion, as well as tumor-associated angiogenesis and are correlated with… CONTINUE READING
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