Heparan sulphate proteoglycans fine-tune mammalian physiology

@article{Bishop2007HeparanSP,
  title={Heparan sulphate proteoglycans fine-tune mammalian physiology},
  author={Joseph R. Bishop and Manuela Schuksz and Jeffrey D Esko},
  journal={Nature},
  year={2007},
  volume={446},
  pages={1030-1037}
}
Heparan sulphate proteoglycans reside on the plasma membrane of all animal cells studied so far and are a major component of extracellular matrices. Studies of model organisms and human diseases have demonstrated their importance in development and normal physiology. A recurrent theme is the electrostatic interaction of the heparan sulphate chains with protein ligands, which affects metabolism, transport, information transfer, support and regulation in all organ systems. The importance of these… CONTINUE READING
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