Heparan sulfates mediate pressure-induced increase in lung endothelial hydraulic conductivity via nitric oxide/reactive oxygen species.

@article{Dull2007HeparanSM,
  title={Heparan sulfates mediate pressure-induced increase in lung endothelial hydraulic conductivity via nitric oxide/reactive oxygen species.},
  author={Randall O Dull and Ian Mecham and Scott W. McJames},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2007},
  volume={292 6},
  pages={L1452-8}
}
We investigated the nonlinear dynamics of the pressure vs. hydraulic conductivity (L(p)) relationship in lung microvascular endothelial cells and demonstrate that heparan sulfates, an important component of the endothelial glycocalyx, participate in pressure-sensitive mechanotransduction that results in barrier dysfunction. The pressure vs. L(p) relationship was complex, possessing both time- and pressure-dependent components. Pretreatment of lung capillary endothelial cells with heparanase III… CONTINUE READING
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