Heparan sulfate sugar modifications mediate the functions of slits and other factors needed for mouse forebrain commissure development.

@article{Conway2011HeparanSS,
  title={Heparan sulfate sugar modifications mediate the functions of slits and other factors needed for mouse forebrain commissure development.},
  author={Christopher Conway and Kathy M. Howe and Nicole K Nettleton and David J. Price and John O. Mason and Thomas Pratt},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2011},
  volume={31 6},
  pages={
          1955-70
        }
}
Heparan sulfate proteoglycans are cell surface and secretory proteins that modulate intercellular signaling pathways including Slit/Robo and FGF/FGFR. The heparan sulfate sugar moieties on HSPGs are subject to extensive postsynthetic modification, generating enormous molecular complexity that has been postulated to provide increased diversity in the ability of individual cells to respond to specific signaling molecules. This diversity could help explain how a relatively small number of axon… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 30 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 63 REFERENCES

Retinal ganglion cell axon guidance in the mouse optic chiasm: expression and function of robos and slits.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2000
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Robo1 and Robo2 cooperate to control the guidance of major axonal tracts in the mammalian forebrain.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2007
VIEW 10 EXCERPTS
HIGHLY INFLUENTIAL

Robo 1 regulates the

W Andrews, A Liapi, +7 authors LJ Richards
  • development
  • 2006
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

Similar Papers

Loading similar papers…