Heparan sulfate signaling in cancer.

  title={Heparan sulfate signaling in cancer.},
  author={Erik H Knelson and Jasmine C Nee and Gerard C. Blobe},
  journal={Trends in biochemical sciences},
  volume={39 6},
Heparan sulfate (HS) is a biopolymer consisting of variably sulfated repeating disaccharide units. The anticoagulant heparin is a highly sulfated intracellular variant of HS. HS has demonstrated roles in embryonic development, homeostasis, and human disease via non-covalent interactions with numerous cellular proteins, including growth factors and their receptors. HS can function as a co-receptor by enhancing receptor-complex formation. In other contexts, HS disrupts signaling complexes or… CONTINUE READING
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