Heparan sulfate proteoglycans provide a signal to Plasmodium sporozoites to stop migrating and productively invade host cells.

@article{Coppi2007HeparanSP,
  title={Heparan sulfate proteoglycans provide a signal to Plasmodium sporozoites to stop migrating and productively invade host cells.},
  author={Alida Coppi and Rita Tewari and Joseph R. Bishop and Brandy L Bennett and Roger O. Bangerter Lawrence and Jeffrey D Esko and Oliver Billker and Photini Sinnis},
  journal={Cell host & microbe},
  year={2007},
  volume={2 5},
  pages={316-27}
}
Malaria infection is initiated when Anopheles mosquitoes inject Plasmodium sporozoites into the skin. Sporozoites subsequently reach the liver, invading and developing within hepatocytes. Sporozoites contact and traverse many cell types as they migrate from skin to liver; however, the mechanism by which they switch from a migratory mode to an invasive mode is unclear. Here, we show that sporozoites of the rodent malaria parasite Plasmodium berghei use the sulfation level of host heparan sulfate… CONTINUE READING
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