Heparan sulfate proteoglycan modulates keratinocyte growth factor signaling through interaction with both ligand and receptor.

@article{Larochelle1999HeparanSP,
  title={Heparan sulfate proteoglycan modulates keratinocyte growth factor signaling through interaction with both ligand and receptor.},
  author={William J. Larochelle and Kazuyasu Sakaguchi and N Atabey and Hyae Gyeong Cheon and Yohko Takagi and T Kinaia and Regina M Day and Tsuneharu Miki and Wilson H. Burgess and Donald P Bottaro},
  journal={Biochemistry},
  year={1999},
  volume={38 6},
  pages={1765-71}
}
Keratinocyte growth factor (KGF) is an unusual fibroblast growth factor (FGF) family member in that its activity is largely restricted to epithelial cells, and added heparin/heparan sulfate inhibits its activity in most cell types. The effects of heparan sulfate proteoglycan (HSPG) on binding and signaling by acidic FGF (aFGF) and KGF via the KGFR were studied using surface-bound and soluble receptor isoforms expressed in wild type and mutant Chinese hamster ovary (CHO) cells lacking HSPG. Low… CONTINUE READING

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