Heparan sulfate proteoglycan-dependent induction of axon branching and axon misrouting by the Kallmann syndrome gene kal-1.

@article{Blow2002HeparanSP,
  title={Heparan sulfate proteoglycan-dependent induction of axon branching and axon misrouting by the Kallmann syndrome gene kal-1.},
  author={Hannes E B{\"u}low and Katherine L Berry and Liat H Topper and Elior Peles and Oliver Hobert},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 9},
  pages={6346-51}
}
Kallmann syndrome is a neurological disorder characterized by various behavioral and neuroanatomical defects. The X-linked form of this disease is caused by mutations in the KAL-1 gene, which codes for a secreted molecule that is expressed in restricted regions of the brain. Its molecular mechanism of action has thus far remained largely elusive. We show here that expression of the Caenorhabditis elegans homolog of KAL-1 in selected sensory and interneuron classes causes a highly penetrant… CONTINUE READING

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Development (Cambridge, U.K

E. I. Rugarli, E. Di Schiavi, +6 authors P. Bazzicalupo
(see text). Bülow et al. PNAS April • 2002

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