Heparan sulfate proteoglycan and laminin mediate two different types of neurite outgrowth.

  title={Heparan sulfate proteoglycan and laminin mediate two different types of neurite outgrowth.},
  author={Djennet Hantaz-Ambroise and M Vigny and Jeanine Koenig},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={7 8},
Spinal cord neurons cultured in vitro have been shown to respond to changes in their environment by means of 2 different types of neurite outgrowth: (1) neurite elongation and (2) emergence and branching of newly formed neurites. Culture of spinal cord neurons with heparan sulfate proteoglycan (HSPG) medium resulted in a 3-fold increase in neurite elongation compared to the control. Extensive branching was seen when neurons were cultured in laminin-supplemented culture medium. HSPG-induced… CONTINUE READING
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