Heparan sulfate potentiates the autocrine action of basic fibroblast growth factor in astrocytes: an in vivo and in vitro study.

@article{GmezPinilla1997HeparanSP,
  title={Heparan sulfate potentiates the autocrine action of basic fibroblast growth factor in astrocytes: an in vivo and in vitro study.},
  author={Fernando G{\'o}mez-Pinilla and Steven U. Miller and J Choi and Carl Cotman},
  journal={Neuroscience},
  year={1997},
  volume={76 1},
  pages={137-45}
}
Increasing evidence indicates that heparan sulfate proteoglycans have a critical role in the regulation of the activity of basic fibroblast growth factor by interacting with it or its receptor. In this study we examined the possibility that heparan sulfate can modulate the basic fibroblast growth factor system at a more fundamental level than activity regulation, by influencing the synthesis of basic fibroblast growth factor and its receptor messenger RNAs. Previous studies in vitro indicate… CONTINUE READING

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Cellular and Molecular Life Sciences CMLS • 1998

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