Heparan sulfate modification of the transmembrane receptor CD47 is necessary for inhibition of T cell receptor signaling by thrombospondin-1.

@article{Kaur2011HeparanSM,
  title={Heparan sulfate modification of the transmembrane receptor CD47 is necessary for inhibition of T cell receptor signaling by thrombospondin-1.},
  author={Sukhbir Kaur and Svetlana A. Kuznetsova and Michael L. Pendrak and John M. Sipes and Martin J. Romeo and Zhuqing Li and Lijuan Zhang and David D. Roberts},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 17},
  pages={14991-5002}
}
Cell surface proteoglycans on T cells contribute to retroviral infection, binding of chemokines and other proteins, and are necessary for some T cell responses to the matricellular glycoprotein thrombospondin-1. The major cell surface proteoglycans expressed by primary T cells and Jurkat T cells have an apparent M(r) > 200,000 and are modified with chondroitin sulfate and heparan sulfate chains. Thrombospondin-1 bound in a heparin-inhibitable manner to this proteoglycan and to a soluble form… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

Similar Papers

Loading similar papers…