Heparan sulfate fibroblast growth factor receptor complex: structure-function relationships.

@article{Mckeehan1994HeparanSF,
  title={Heparan sulfate fibroblast growth factor receptor complex: structure-function relationships.},
  author={Wallace L. Mckeehan and Mikio Kan},
  journal={Molecular reproduction and development},
  year={1994},
  volume={39 1},
  pages={69-81; discusison 81-2}
}
Splice variations in genes coding for the transmembrane FGF receptor (FGFR) result in isoforms that vary in the ectodomain, intracellular juxtamembrane domain, and the intracellular kinase domain. An analysis of biochemical functions of distinct recombinant isoforms expressed in baculoviral-infected insect cells allowed generation of models for function of splice variants in both the ecto- and intracellular domains. A structural model for the ectodomain of the FGFR is proposed as follows… CONTINUE READING

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