Heparan sulfate facilitates Rift Valley fever virus entry into the cell.

@article{Boer2012HeparanSF,
  title={Heparan sulfate facilitates Rift Valley fever virus entry into the cell.},
  author={S M de Boer and Jeroen Kortekaas and Cornelis A M de Haan and Peter J. M. Rottier and Rob J. M. Moormann and B J Bosch},
  journal={Journal of virology},
  year={2012},
  volume={86 24},
  pages={13767-71}
}
Rift Valley fever virus (RVFV), an emerging arthropod-borne pathogen, has a broad host and cell tropism. Here we report that the glycosaminoglycan heparan sulfate, abundantly present on the surface of most animal cells, is required for efficient entry of RVFV. Entry was significantly reduced by preincubating the virus inoculum with highly sulfated heparin… CONTINUE READING