Heparan Sulfate Proteoglycan Syndecan Promotes Axonal and Myotube Guidance by Slit/Robo Signaling

@article{Steigemann2004HeparanSP,
  title={Heparan Sulfate Proteoglycan Syndecan Promotes Axonal and Myotube Guidance by Slit/Robo Signaling},
  author={Patrick Steigemann and Andreas Molitor and Sonja Fellert and Herbert Jaeckle and Gerd Vorbrueggen},
  journal={Current Biology},
  year={2004},
  volume={14},
  pages={225-230}
}
Slit, the ligand for the Roundabout (Robo) receptors, is secreted from midline cells of the Drosophila central nervous system (CNS). It acts as a short-range repellent that controls midline crossing of axons and allows growth cones to select specific pathways along each side of the midline. In addition, Slit directs the migration of muscle precursors and ventral branches of the tracheal system, showing that it provides long-range activity beyond the limit of the developing CNS. Biochemical… CONTINUE READING
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finding that overexpression of Sdc in the Slit-secreting

  • S. Rajagopalan, V. Vivancos, E. Nicolas, B. J. Dickson
  • 2000
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