HepG2 cells as an in vitro model for evaluation of cytochrome P450 induction by xenobiotics
@article{Choi2015HepG2CA,
title={HepG2 cells as an in vitro model for evaluation of cytochrome P450 induction by xenobiotics},
author={Jong Min Choi and Soo Jin Oh and Sang Yoon Lee and Ji Hye Im and Jung Min Oh and Chang Seon Ryu and Hui Chan Kwak and Ji-Yoon Lee and Keon Wook Kang and Sang Kyum Kim},
journal={Archives of Pharmacal Research},
year={2015},
volume={38},
pages={691-704}
}Although various in vitro assays have been developed to evaluate the cytochrome P450 (CYP)-inducing potential of drug candidates, there is a continuing need for the development of a reliable model in drug discovery. The objective of the present study was to compare CYP induction by chemicals in HepG2 cells with Huh7, NKNT-3, and reverted NKNT-3 cells. HepG2 cells showed more similarity to human liver than the other cell lines in comparisons of the expression of cellular proteins. In evaluation…
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