HepG2 및 PC12 세포에서 혼합 한약재 발효물의 산화적 스트레스 억제 활성 평가

  title={HepG2 및 PC12 세포에서 혼합 한약재 발효물의 산화적 스트레스 억제 활성 평가},
  author={이윤정 and 김난슬 and 손명수 and 김교남 and 황용일 and 박은주},
  journal={Journal of The Korean Society of Food Science and Nutrition},
This study was carried out to investigate the effect of fermented herbal mixtures (FHMs) in HepG2 and PC12 cells. Two different types of fermented herbal mixtures consisted of Chrysanthemum morifolium, Ganoderma lucidum, Acanthopanax senticosus, Schisandra chinensis, Hovenia dulcis thumb, and Lycii fructus. FHM-A and FHM-B were separately fermented with Prunellae Spica, Portulaca oleracea (FHM-A) and Acorus gramineus, Pycnostelma paniculatum (FHM-B). Total phenolic content of FHM-B was higher… 
1 Citations



국화과 Chrysanthemum속 식물 3종의 항산화 효과

To develop a natural antioxidant from three Chrysanthemum species, flower and shoot extracts of Chrysanthemum frutescens, Chrysanthemum morifolium and Chrysanthemum zawadskii ssp. naktongense were

Antioxidant and Nitrite Scavenging Activities of Acanthopanax senticosus Extract Fermented with Different Mushroom Mycelia

This study was designed to investigate the antioxidant activities (ORAC value, DPPH and ABTS radical scavenging activity, FRAP activity, and reducing power) and nitrite scavenging activities of

Protective Effects of the Fermented Laminaria japonica Extract on Oxidative Damage in LLC-PK1 Cells

Results indicate that BFLJ protects the LLC-PK1 cells against AAPH-induced cell damage by inhibiting lipid peroxidation formation and increasing antioxidant enzyme activities and glutathione concentration.

Influence of quercetin and rutin on growth and antioxidant defense system of a human hepatoma cell line (HepG2)

The results indicate that both natural antioxidants induce favorable changes in the antioxidant defense system of cultured HepG2 that prevent or delay conditions which favor cellular oxidative stress.

Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK-HEP-1

Molecular evidence is provided to demonstrate that wogonin and fisetin had effective cytotoxic effects through apoptosis induction in hepatocellular carcinoma cells SK-HEP-1; activation of caspase 3 cascade, induction of p53 protein and alternative expression of p21Waf/Cip-1 protein were involved.

Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cells.

The first evidence that fisetin could be developed as an agent against PCa is provided, with a decrease in the viability of LNCaP, CWR22Rupsilon1 and PC-3 cells and activation of caspases.

The water extract of Angelica Sinensis Radix protects cultured PC12 cells against oxidative stress: suppression of reactive oxygen species and activation of anti-oxidant response elements -

Interestingly, the protective effect of ASR extract in PC12 cells were insignificant when challenging by insults of -amlyoid (for Alzheimer's disease) and MPP+ (for Parkinson’s disease), which might be useful in developing health food supplements for disease prevention in future.

Ethanol extract of Cirsium japonicum attenuates hepatic lipid accumulation via AMPK activation in human HepG2 cells

The results of the present study indicated that the positive effects of CJ extract on high-fat diet-induced hepatic TG accumulation were mediated via the AMPK signaling pathway, indicating a potential target for the preventative treatment of NAFLD.

Heme oxygenase-1 inducing constituent of Prunella vulgaris in HepG2 cells.

Investigation of structure-related HO-1 inducing activity suggested that the hydroxyl group at the C-23 position in the ursane skeleton is important for this activity.

Medicinal Herb Extracts Attenuate 1-Chloro-2,4dinitrobenzene-induced Development of Atopic Dermatitis-like Skin Lesions

Results suggest that a mixture of GS, GC, and BSP in a proportion of 3:1:1 (GGB-1) may contribute to the relief of AD symptoms and may be considered an excellent candidate for an AD therapeutic drug.