Hensin Remodels the Apical Cytoskeleton and Induces Columnarization of Intercalated Epithelial Cells: Processes that Resemble Terminal Differentiation

@article{Vijayakumar1999HensinRT,
  title={Hensin Remodels the Apical Cytoskeleton and Induces Columnarization of  Intercalated Epithelial Cells: Processes that Resemble Terminal Differentiation },
  author={Soundaraparan Vijayakumar and Jiro Takito and Chinami Hikita and Qais Al-Awqati},
  journal={The Journal of Cell Biology},
  year={1999},
  volume={144},
  pages={1057 - 1067}
}
Intercalated epithelial cells exist in a spectrum of phenotypes; at one extreme, beta cells secrete HCO3 by an apical Cl/HCO3 exchanger and a basolateral H+ ATPase. When an immortalized beta cell line is seeded at high density it deposits in its extracellular matrix (ECM) a new protein, hensin, which can reverse the polarity of several proteins including the Cl/HCO3 exchanger (an alternately spliced form of band 3) and the proton translocating ATPase. When seeded at low density and allowed to… CONTINUE READING
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