Henipavirus pathogenesis in human respiratory epithelial cells.

  title={Henipavirus pathogenesis in human respiratory epithelial cells.},
  author={Olivier Escaffre and Viktoriya Borisevich and Joseph R. Carmical and D. Prusak and Joseph Prescott and Heinz Feldmann and Barry Rockx},
  journal={Journal of virology},
  volume={87 6},
Hendra virus (HeV) and Nipah virus (NiV) are deadly zoonotic viruses for which no vaccines or therapeutics are licensed for human use. Henipavirus infection causes severe respiratory illness and encephalitis. Although the exact route of transmission in human is unknown, epidemiological studies and in vivo studies suggest that the respiratory tract is important for virus replication. However, the target cells in the respiratory tract are unknown, as are the mechanisms by which henipaviruses can… CONTINUE READING