Hen1 is required for oocyte development and piRNA stability in zebrafish.

  title={Hen1 is required for oocyte development and piRNA stability in zebrafish.},
  author={Leonie M Kamminga and Maartje J. Luteijn and Marjo J. den Broeder and Stefan Redl and Lucas J. T. Kaaij and Elke F. Roovers and Peter Ladurner and Eugene Berezikov and Ren{\'e} F Ketting},
  journal={The EMBO journal},
  volume={29 21},
Piwi-interacting RNAs (piRNAs) are germ line-specific small RNA molecules that have a function in genome defence and germ cell development. They associate with a specific class of Argonaute proteins, named Piwi, and function through an RNA interference-like mechanism. piRNAs carry a 2'-O-methyl modification at their 3' end, which is added by the Hen1 enzyme. We show that zebrafish hen1 is specifically expressed in germ cells and is essential for maintaining a female germ line, whereas it is… CONTINUE READING


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