Hemozoin (malarial pigment) inhibits differentiation and maturation of human monocyte-derived dendritic cells: a peroxisome proliferator-activated receptor-gamma-mediated effect.

@article{Skorokhod2004HemozoinP,
  title={Hemozoin (malarial pigment) inhibits differentiation and maturation of human monocyte-derived dendritic cells: a peroxisome proliferator-activated receptor-gamma-mediated effect.},
  author={Oleksii A Skorokhod and Massimo Alessio and Benjamin Mordm{\"u}ller and Paolo Arese and Evelin Schwarzer},
  journal={Journal of immunology},
  year={2004},
  volume={173 6},
  pages={4066-74}
}
Acute and chronic Plasmodium falciparum malaria are accompanied by severe immunodepression possibly related to subversion of dendritic cells (DC) functionality. Phagocytosed hemozoin (malarial pigment) was shown to inhibit monocyte functions related to immunity. Hemozoin-loaded monocytes, frequently found in circulation and adherent to endothelia in malaria, may interfere with DC development and play a role in immunodepression. Hemozoin-loaded and unloaded human monocytes were differentiated in… CONTINUE READING

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