Hemostatic alterations in liver disease: a review on pathophysiology, clinical consequences, and treatment.

@article{Lisman2007HemostaticAI,
  title={Hemostatic alterations in liver disease: a review on pathophysiology, clinical consequences, and treatment.},
  author={Ton Lisman and Frank W G Leebeek},
  journal={Digestive surgery},
  year={2007},
  volume={24 4},
  pages={250-8}
}
In most patients with acute or chronic liver failure, extensive changes in all pathways contributing to hemostasis are found. These hemostatic alterations concern both pro- and anti-hemostatic pathways, and therefore the net result of the hemostatic unbalance is unclear. Although it is generally believed that patients with liver disease have a hemostasis-related bleeding tendency, this concept is challenged in recent literature. Although the bleeding problems in patients with liver disease are… CONTINUE READING
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No evidence for an intrinsic platelet defect in patients with liver cirrhosis – studies under flow conditions

  • T Lisman, J Adelmeijer, PG deGroot, HL Janssen, FW Leebeek
  • J Thromb Haemost
  • 2006

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