Hemorrhagic metalloproteinases from snake venoms.

  title={Hemorrhagic metalloproteinases from snake venoms.},
  author={J{\'o}n Bragi Bjarnason and Jay William Fox},
  journal={Pharmacology & therapeutics},
  volume={62 3},
One of the more significant consequences of crotalid envenomation is hemorrhage. Over the past 50 years of investigation, it is clear that the primary factors responsible for hemorrhage are metalloproteinases present in the venom of these snakes. The biochemical basis for their activity is the proteolytic destruction of basement membrane and extracellular matrix surrounding capillaries and small vessels. These proteinase toxins may also interfere with coagulation, thus complementing loss of… CONTINUE READING
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