Hemorrhagic activity and muscle damaging effect of Pseudomonas aeruginosa metalloproteinase (elastase).

@article{Komori2001HemorrhagicAA,
  title={Hemorrhagic activity and muscle damaging effect of Pseudomonas aeruginosa metalloproteinase (elastase).},
  author={Yumiko Komori and Tsunemasa Nonogaki and Toshiaki Nikai},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={2001},
  volume={39 9},
  pages={1327-32}
}
Pseudomonas aeruginosa elastase, a Bacillus subtilis thermolysin-like zinc-proteinase was examined for hemorrhagic activity and its effect on muscle and endothelial cells. Subcutaneous and intramuscular injections of elastase into mice caused severe hemorrhage with an acute increase of creatine phosphokinase activity in serum. The elastase also possessed fibrinogenolytic and fibrinolytic activities. The Aalpha and Bbeta chains of fibrinogen were completely hydrolyzed as demonstrated by their… CONTINUE READING

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