Hemorrhagic acquired factor XIII (13) deficiency and acquired hemorrhaphilia 13 revisited.

  title={Hemorrhagic acquired factor XIII (13) deficiency and acquired hemorrhaphilia 13 revisited.},
  author={Akitada Ichinose},
  journal={Seminars in thrombosis and hemostasis},
  volume={37 4},
Coagulation factor XIII (F13) circulates in blood as a heterotetramer composed of an A subunit dimer and a B subunit dimer. It is activated by thrombin and crosslinks fibrin monomers. Congenital F13 deficiency demonstrates a lifelong bleeding tendency, abnormal wound healing, and recurrent miscarriages, and it first manifests as umbilical bleeding after birth. In contrast, secondary F13 deficiencies due to its overconsumption and/or hypobiosynthesis by disseminated intravascular coagulation… CONTINUE READING
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