• Biology, Medicine
  • Published in Journal of immunology 1991

Hemorrhage induces enhanced Kupffer cell cytotoxicity while decreasing peritoneal or splenic macrophage capacity. Involvement of cell-associated tumor necrosis factor and reactive nitrogen.

@article{Ayala1991HemorrhageIE,
  title={Hemorrhage induces enhanced Kupffer cell cytotoxicity while decreasing peritoneal or splenic macrophage capacity. Involvement of cell-associated tumor necrosis factor and reactive nitrogen.},
  author={Alfred Ayala and Marie-th{\'e}r{\`e}se Perrin and Peter Wang and Wolfgang Ertel and Irshad H. Chaudry},
  journal={Journal of immunology},
  year={1991},
  volume={147 12},
  pages={
          4147-54
        }
}
Studies indicate that simple hemorrhage produces a profound depression of cell-mediated immunity, thereby contributing to an enhanced susceptibility to septic challenge in the host. However, it remains unknown whether or not the macrophages' cytotoxic capacity is altered after hemorrhage. To study this, C3H/HeN mice were bled to and maintained at a blood pressure of 35 mm Hg for 60 min, and adequately resuscitated. Mice were then killed at 2 or 24 h after hemorrhage to obtain peritoneal… CONTINUE READING

Citations

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Liver cytokine production and ICAM-1 expression following bone fracture, tissue trauma, and hemorrhage in middle-aged mice.

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Lipopolysaccharide-binding protein modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation.

  • American journal of physiology. Gastrointestinal and liver physiology
  • 2006
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