Hemorrhage induced by snake venom metalloproteinases: biochemical and biophysical mechanisms involved in microvessel damage.

@article{Gutirrez2005HemorrhageIB,
  title={Hemorrhage induced by snake venom metalloproteinases: biochemical and biophysical mechanisms involved in microvessel damage.},
  author={Jos{\'e} Mar{\'i}a Guti{\'e}rrez and Alexandra Rucavado and Teresa Escalante and Cec{\'i}lia D{\'i}az},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={2005},
  volume={45 8},
  pages={997-1011}
}
Zinc-dependent metalloproteinases are responsible for the hemorrhagic activity characteristic of viperid snake venoms. Snake venom metalloproteinases (SVMPs) are classified in various groups (P-I-IV), according to their domain composition. P-III SVMPs, comprising metalloproteinase, disintegrin-like and cysteine-rich domains, exert more potent hemorrhagic activity than P-I SVMPs, which present only the metalloproteinase domain. SVMPs degrade various components of the basement membrane and are… CONTINUE READING
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