Hemorrhage alters plasma and cardiac enkephalins and catecholamines in anesthetized dogs.

@article{Mateo1995HemorrhageAP,
  title={Hemorrhage alters plasma and cardiac enkephalins and catecholamines in anesthetized dogs.},
  author={Z Mateo and Leslie D Napier and J F Gaugl and Barbara A. Barron and J. L. Caffrey},
  journal={The American journal of physiology},
  year={1995},
  volume={269 6 Pt 2},
  pages={H2082-9}
}
Intrinsic cardiac enkephalins participate in circulatory regulation either through the modification of vagal control or vasomotor sympathetic control. We extracted, chromatographed, and assayed plasma and myocardial enkephalins from anesthetized dogs under control conditions and during hemorrhagic hypotension (2 h at 40 mmHg). Blood samples were collected at intervals during the experiment. Blood gases were stable, pH declined to 7.1, and heart rate rose. Plasma catecholamines increased and… CONTINUE READING