Hemorheological Effects of Valsartan in L-NAME Induced Hypertension in Rats

  title={Hemorheological Effects of Valsartan in L-NAME Induced Hypertension in Rats},
  author={A. S. Silva-Herdade and Carlota Saldanha},
Animal models are a useful tool, for example, in the study of hypertension, but its use requires robust knowledge and well characterized models in order to extrapolate the obtained results. Nitric oxide is an important regulator of vascular function and blood pressure. The chronic administration of nitric oxide synthase (NOS) inhibitors provides an animal experimental model of hypertension. Our study aims to investigate the hemorheological effects of (i) N -nitro-L-arginine methyl ester (L-NAME… CONTINUE READING
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