Hemophagocytosis-mediated keratinization in oral carcinoma in situ and squamous cell carcinoma: a possible histopathogenesis of keratin pearls.

@article{AlEryani2013HemophagocytosismediatedKI,
  title={Hemophagocytosis-mediated keratinization in oral carcinoma in situ and squamous cell carcinoma: a possible histopathogenesis of keratin pearls.},
  author={Kamal Al-Eryani and Jun Cheng and Tatsuya Abe and Manabu Yamazaki and Satoshi Maruyama and Masayuki Tsuneki and Ahmed Abdelaziz Mohamed Essa and Hamzah Ali Babkair and Takashi Saku},
  journal={Journal of cellular physiology},
  year={2013},
  volume={228 10},
  pages={
          1977-88
        }
}
Although the histopathogenetic process of keratin pearls is still poorly understood, acceleration of keratinization in squamous cell carcinoma (SCC) cells may represent one possible therapeutic avenue. Based on our histopathological observations, we have hypothesized that SCC cells are keratinized by phagocytosis of extravasated erythrocytes. To confirm this hypothesis, we firstly examined immature keratin pearls in oral carcinoma in situ (CIS) and mature ones in SCC by immunohistochemistry… CONTINUE READING
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