Hemophagocytic syndrome in patients with acute myeloid leukemia undergoing intensive chemotherapy.

@article{Delavigne2014HemophagocyticSI,
  title={Hemophagocytic syndrome in patients with acute myeloid leukemia undergoing intensive chemotherapy.},
  author={Karen Delavigne and Emilie B{\'e}rard and Sarah Bertoli and J. M. Corre and Eliane Duchayne and C{\'e}cile Demur and V{\'e}ronique Mansat-De Mas and C{\'e}cile Borel and Muriel Picard and Muriel Alvarez and Audrey Sarry and Françoise Huguet and Christian R{\'e}cher},
  journal={Haematologica},
  year={2014},
  volume={99 3},
  pages={474-80}
}
Hemophagocytic lymphohistiocytosis is a condition of immune dysregulation characterized by severe organ damage induced by a hyperinflammatory response and uncontrolled T-cell and macrophage activation. Secondary hemophagocytic lymphohistiocytosis typically occurs in association with severe infections or malignancies. Patients with acute myeloid leukemia may be prone to develop hemophagocytic lymphohistiocytosis because of an impaired immune response and a high susceptibility to severe… CONTINUE READING