Hemophagocytic macrophages constitute a major compartment of heme oxygenase expression in sepsis

@article{Schaer2006HemophagocyticMC,
  title={Hemophagocytic macrophages constitute a major compartment of heme oxygenase expression in sepsis},
  author={Dominik J Schaer and C A Schaer and Gabriele Schoedon and Alexander Imhof and Michael Odo Kurrer},
  journal={European Journal of Haematology},
  year={2006},
  volume={77},
  pages={432 - 436}
}
OBJECTIVES Uncontrolled macrophage activation with hemophagocytosis is a distinctive feature of hemophagocytic syndromes (HPS). We examined whether lympho-histiocytic infiltration of the bone marrow and liver, as well as hemo-/erythrophagocytosis also occurs during sepsis and whether this process could account for the increased production of anti-inflammatory heme-oxygenase (HO-1) products observed during sepsis. METHODS Hemophagocytosis and expression of CD163, HO-1, ferritin as well as CD8… CONTINUE READING

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