Hemophagocytic lymphohistiocytosis in syntaxin-11-deficient mice: T-cell exhaustion limits fatal disease.

@article{Koegl2013HemophagocyticLI,
  title={Hemophagocytic lymphohistiocytosis in syntaxin-11-deficient mice: T-cell exhaustion limits fatal disease.},
  author={Tamara Koegl and J{\"u}rgen M{\"u}ller and Birthe Jessen and Annette Schmitt-Graeff and Gritta E. Janka and Stephan Ehl and Udo zur Stadt and Peter Aichele},
  journal={Blood},
  year={2013},
  volume={121 4},
  pages={604-13}
}
Syntaxin-11 (Stx11), an atypical member of the SNARE protein family, is part of the cytolytic machinery of T and NK cells and involved in the fusion of lytic granules with the plasmamembrane. Functional loss of syntaxin-11 in humans causes defective degranulation and impaired cytolytic activity of T and NK cells. Furthermore, patients with STX11 deficiency… CONTINUE READING