Hemophagocytic lymphohistiocytosis: pathogenesis and treatment.

@article{Janka2013HemophagocyticLP,
  title={Hemophagocytic lymphohistiocytosis: pathogenesis and treatment.},
  author={Gritta E. Janka and Kai Lehmberg},
  journal={Hematology. American Society of Hematology. Education Program},
  year={2013},
  volume={2013},
  pages={605-11}
}
Hemophagocytic lymphohistiocytosis (HLH) is not an independent disease but rather a life-threatening clinical syndrome that occurs in many underlying conditions and in all age groups. HLH is the consequence of a severe, uncontrolled hyperinflammatory reaction that in most cases is triggered by an infectious agent. Persistent stimulation of lymphocytes and histiocytes results in hypercytokinemia, leading to the characteristic symptoms of HLH. Genetic defects in familial HLH and in… CONTINUE READING
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