Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease.

@article{Vinchi2016HemopexinTR,
  title={Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease.},
  author={Francesca Vinchi and Milene Costa da Silva and Giada Ingoglia and Sara Petrillo and Nathan Brinkman and Adrian W. Zuercher and Adelheid Cerwenka and Emanuela Tolosano and Martina U. Muckenthaler},
  journal={Blood},
  year={2016},
  volume={127 4},
  pages={473-86}
}
Hemolytic diseases, such as sickle cell anemia and thalassemia, are characterized by enhanced release of hemoglobin and heme into the circulation, heme-iron loading of reticulo-endothelial system macrophages, and chronic inflammation. Here we show that in addition to activating the vascular endothelium, hemoglobin and heme excess alters the macrophage phenotype in sickle cell disease. We demonstrate that exposure of cultured macrophages to hemolytic aged red blood cells, heme, or iron causes… CONTINUE READING
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