Hemolytic-uremic syndrome and T-cryptantigen exposure by neuraminidase-producing pneumococci: an emerging problem?

@article{Novak1983HemolyticuremicSA,
  title={Hemolytic-uremic syndrome and T-cryptantigen exposure by neuraminidase-producing pneumococci: an emerging problem?},
  author={Robert W Novak and Colin R Martin and Edmund N Orsini},
  journal={Pediatric pathology},
  year={1983},
  volume={1 4},
  pages={409-13}
}
Hemolytic anemia, thrombocytopenia, and renal failure form a constellation of complications observed in patients infected with neuraminidase-producing pneumococci. The circulating enzyme causes exposure of the T-cryptantigen on cell surfaces to which most people possess a naturally occurring antibody. Antigen-antibody interaction activates effector systems that lead to the clinical manifestations. The syndrome is most frequently seen in infants, in whom it carries more than a 50% mortality rate… CONTINUE READING