Hemolytic anemias and erythrocyte enzymopathies.

  title={Hemolytic anemias and erythrocyte enzymopathies.},
  author={W N Valentine and Kouichi R. Tanaka and Donald E. Paglia},
  journal={Annals of internal medicine},
  volume={103 2},
The human erythrocyte generates high-energy adenosine triphosphate by anaerobic glycolysis and cycles oxidized and reduced nicotinamide adenine dinucleotide phosphate by the aerobic pentose phosphate shunt pathway. Certain enzymopathies of the pentose phosphate shunt are associated with hemolysis resulting from oxidative denaturation of hemoglobin. Glucose-6-phosphate dehydrogenase deficiency, an X-chromosome-linked disorder, is the prototype of these diseases and is genetically and clinically… CONTINUE READING


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