Hemolytic Potential of Tafenoquine in Female Volunteers Heterozygous for Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency (G6PD Mahidol Variant) versus G6PD-Normal Volunteers.

Abstract

Tafenoquine is an 8-aminoquinoline under investigation for the prevention of relapse in Plasmodium vivax malaria. This open-label, dose-escalation study assessed quantitatively the hemolytic risk with tafenoquine in female healthy volunteers heterozygous for the Mahidol487A glucose-6-phosphate dehydrogenase (G6PD)-deficient variant versus G6PD-normal… (More)
DOI: 10.4269/ajtmh.16-0779

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@article{Rueangweerayut2017HemolyticPO, title={Hemolytic Potential of Tafenoquine in Female Volunteers Heterozygous for Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency (G6PD Mahidol Variant) versus G6PD-Normal Volunteers.}, author={Ronnatrai Rueangweerayut and Germana Bancone and Emma J Harrell and Andrew P. Beelen and Supornchai Kongpatanakul and Joerg J. Moehrle and Vicki M. Rousell and Khadeeja Mohamed and Ammar T. Qureshi and Sushma Narayan and Nushara Yubon and Ann Miller and François H Nosten and Lucio Luzzatto and Stephan Duparc and J. P. Kleim and Justin Anton Green}, journal={The American journal of tropical medicine and hygiene}, year={2017}, volume={97 3}, pages={702-711} }