Hemolysis of erythrocytes by granulysin-derived peptides but not by granulysin.

@article{Li2005HemolysisOE,
  title={Hemolysis of erythrocytes by granulysin-derived peptides but not by granulysin.},
  author={Qing Li and Chen Yang Dong and Anmei Deng and Masao Katsumata and Ari Nakadai and Tomoyuki Kawada and Satoshi Okada and Carol A. Clayberger and Alan M. Krensky},
  journal={Antimicrobial agents and chemotherapy},
  year={2005},
  volume={49 1},
  pages={388-97}
}
Granulysin, a 9-kDa protein localized in human cytolytic T lymphocytes and natural killer cell granules, is cytolytic against tumors and microbes but not against red blood cells. Synthetic peptides corresponding to the central region of granulysin recapitulate the lytic activity of the intact molecule, and some peptides cause hemolysis of red blood cells. Peptides in which cysteine residues were replaced by serine maintain their activity against microbes but lose activity against human cells… CONTINUE READING