Hemolysis in sickle cell mice causes pulmonary hypertension due to global impairment in nitric oxide bioavailability.

@article{Hsu2007HemolysisIS,
  title={Hemolysis in sickle cell mice causes pulmonary hypertension due to global impairment in nitric oxide bioavailability.},
  author={Lewis L. Hsu and Hunter C. Champion and Sally A Campbell-Lee and Trinity J. Bivalacqua and Elizabeth Manci and Bhalchandra A. Diwan and Daniel M. Schimel and Audrey E Cochard and Xunde Wang and Alan N Schechter and Constance Tom Noguchi and Mark T Gladwin},
  journal={Blood},
  year={2007},
  volume={109 7},
  pages={3088-98}
}
Pulmonary hypertension is a highly prevalent complication of sickle cell disease and is a strong risk factor for early mortality. However, the pathophysiologic mechanisms leading to pulmonary vasculopathy remain unclear. Transgenic mice provide opportunities for mechanistic studies of vascular pathophysiology in an animal model. By microcardiac catheterization, all mice expressing exclusively human sickle hemoglobin had pulmonary hypertension, profound pulmonary and systemic endothelial… CONTINUE READING

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