Hemolysis-associated endothelial dysfunction mediated by accelerated NO inactivation by decompartmentalized oxyhemoglobin.

@article{Minneci2005HemolysisassociatedED,
  title={Hemolysis-associated endothelial dysfunction mediated by accelerated NO inactivation by decompartmentalized oxyhemoglobin.},
  author={Peter C. Minneci and Katherine J. Deans and Huang Zhi and Peter S T Yuen and Robert A Star and Steven M. Banks and Alan N Schechter and C Natanson and Mark T Gladwin and Steven B. Solomon},
  journal={The Journal of clinical investigation},
  year={2005},
  volume={115 12},
  pages={3409-17}
}
During intravascular hemolysis in human disease, vasomotor tone and organ perfusion may be impaired by the increased reactivity of cell-free plasma hemoglobin (Hb) with NO. We experimentally produced acute intravascular hemolysis in a canine model in order to test the hypothesis that low levels of decompartmentalized or cell-free plasma Hb will severely reduce NO bioavailability and produce vasomotor instability. Importantly, in this model the total intravascular Hb level is unchanged; only the… CONTINUE READING