Hemolysin of uropathogenic Escherichia coli: A cloak or a dagger?

  title={Hemolysin of uropathogenic Escherichia coli: A cloak or a dagger?},
  author={Laura C. Ristow and R A Welch},
  journal={Biochimica et biophysica acta},
  volume={1858 3},
Hemolysin from uropathogenic Escherichia coli (UPEC) is a hemolytic and cytotoxic protein active against a broad range of species and cell types. Expression of hemolysin correlates with severity of infection, as up to 78% of UPEC isolates from pyelonephritis cases express hemolysin. Despite decades of research on hemolysin activity, the mechanism of intoxication and the function of hemolysin in UPEC infection remain elusive. Early in vitro research established the role of hemolysin as a lytic… CONTINUE READING

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